维普医疗科学家简介：李春晖

2021-06-04 12:48

英国邓迪大学生物医学工程硕士、机械工程博士

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研究方向：光声成像 、组织工程中的光学活组织检查和功能成像、表面声波弹性成像和剪切波弹性成像， 成像系统在光学，超声波和MRI中的操作、模拟和数字电子技术、包括高能激光脉冲系统，干涉仪和光学相干断层扫描的生物医学光学。

研究经历

2013 年至今，英国邓迪大学医学院和科学工程学院影像与技术部门

  • 利用定量光学相干弹性成像(OCE) 在前列腺癌和乳腺癌中发现组织并解析。

  • 3D 建模以及应用于优化手术流程。

  • 利用振动弹性成像、剪力波弹性成像和表面波弹性成像，进行弹性分析和早期癌症诊断与治疗监测。

  • 利用光学相干断层扫描进行体内微血管绘制。


2009-2014 年，英国邓迪大学工程、数学与物理学院，华盛顿大学生物工程系

  • 利用表面声波(SAW) 方法定量确定皮肤的生物力学特性，结合相敏感光学相干断层扫描(PhS-OCT)。

  • 利用激光超声波测量人体晶状体和角膜生物力学特性。

  • 利用剪力波方法测量鼠大脑生物力学特性。

  • 全光学光声成像系统。


2009 年，邓迪大学工程、数学与物理学院。

  • 优化新机械人系统协助MRI 引导乳腺癌手术。


2007-2008 年澳大利亚RMIT 大学电气与计算机工程学院

  • 设计制造电子生物反馈系统，提高睡眠质量和调节。


2006-2007 天津大学精密仪表和光电子工程学院

  • 设计制造牙科仪器水路的臭氧水浓度检测与控制系统。

  • 成像流式细胞仪。

  • ECG、EEG 和脊神经探测仪放大器。


研究兴趣

  • 生物光子学/生物医学光学；

  • 开发应用利用相干层析(OCT) 和共聚焦层析技术的功能光学成像；

  • 光声成像：

  • 激光多普勒，色斑和内源光信号成像；

  • 激光超声波；

  • 光在生物组织中传播；


外联经历

同行审核：

Journal of Biomedical Optics

Optics letters

Optics express

Biomedical optics express

Lasers in Surgery & Medicine

Optical Society of America A

Journal of Biophotonics

Journal of Selected Topics in Quantum Electronics


技能

研究项目管理与数据分析的常规技能。具体专业技术和兴趣：

计算机技能：     

  • 编程语言：Matlab、C++、VB 和LabView。

  • 有限元分析：ANSYS。

  • CAD 设计：Auto CAD 和SolidWorks。

  • 3D 可视化工具：Amira。


研究技能：  

  • 弹性成像：表面声波弹性成像和剪力波弹性成像。

  • 光学、超声波和MRI 成像系统工作。

  • 模拟和数字电技术。

  • 生物医学光学，包括高能激光脉冲系统、干涉仪和光学相干断层扫描。

  • 动物操作和组织操作，包括鼠、灵长类和体外人体组织。



PUBLICATIONS

Peer reviewed journal paper (IF-impact factor)

  1. McMillan, L., O'Mahoney, P., Feng, K., Zheng, K., Barnard, I.R., Li, C., Ibbotson, S., Eadie, E., Brown, C.T.A. and Wood, K. (2020), Development of a Predictive Monte Carlo Radiative Transfer Model for Ablative Fractional Skin Lasers. Lasers Surg Med. https://doi.org/10.1002/lsm.23335

  2. Zhang, D, Li, C, Huang, Z. Relaxation time constant based optical coherence elastography. J. Biophotonics. 2020; 13:e201960233. https://doi.org/10.1002/jbio.201960233 (corresponding author)

  3. Zhang, D, Wang, J, Li, C*, Huang, Z. Optimal stimulation frequency for vibrational optical coherence elastography. J. Biophotonics. 2020 (corresponding author)

  4. Mitchell A. Kirby, Kanheng Zhou, John J. Pitre, Liang Gao, David S. Li, Ivan M. Pelivanov, Shaozhen Song, Chunhui Li, Zhihong Huang, Tueng T. Shen, Ruikang K. Wang, Matthew O'Donnell, "Spatial resolution in dynamic optical coherence elastography," J. Biomed. Opt. 24(9) 096006 (18 September 2019).

  5. Zhu, S. , Corsetti, S. , Wang, Q. , Li, C. , Huang, Z. and Nabi, G. (2019), Optical sensory arrays for the detection of urinary bladder cancer related volatile organic compounds (VOCs). J. Biophotonics. Accepted Author Manuscript.

  6. Kanheng Zhou, Chunhui Li*, Siping Chen, Ghulam Nabi and Zhihong Huang, Feasibility study of using the dispersion of surface acoustic wave (SAW) impulse for viscoelasticity characterization in tissue mimicking phantoms, 2018 Journal of Biophotonics, DOI: 10.1002/jbio.201800177. (corresponding author)

  7. Wei Cheng; Li, Chunhui; Szewczyk-Bieda, Magdalena; Upreti, Dilip; Lang, Stephen; Huang, Zhihong; Nabi, Ghulam.Performance characteristics of transrectal shear wave elastography (SWE) imaging in the evaluation of clinically localised prostate cancer: a prospective study.2018 The Journal of Urology DOI 10.1016/j.juro.2018.03.116

  8. Ling Yuting, Chunhui Li, Kanheng Zhou, Guangying Guan, Paul L Appleton, Stephen Lang, David McGloin, Zhihong Huang & Ghulam Nabi Microscale characterization of prostate biopsies tissues using optical coherence elastography and second harmonic generation imaging, Laboratory Investigation volume 98, pages 380–390 (2017) doi:10.1038/labinvest.2017.132

  9. Zhou K, Le N, Huang Z, Li C*, High-intensity-focused ultrasound and phase-sensitive optical coherence tomography for high resolution surface acoustic wave elastography. J. Biophotonics. 2017; 11:e201700051. https://doi.org/10.1002/jbio.201700051 (corresponding author)

  10. Ling, Y, Li, C, Feng, K, Palmer, S, Appleton, PL, Lang, S, McGloin, D, Huang, Z & Nabi, G 2016, 'Second harmonic generation (SHG) imaging of cancer heterogeneity in ultrasound guided biopsies of prostate in men suspected with prostate cancer' Journal of Biophotonics.

  11. Ling, Y, Li, C, Feng, K, Duncan, R, Eisma, R, Huang, Z & Nabi, G 2016, 'Effects of fixation and preservation on tissue elastic properties measured by quantitative optical coherence elastography (OCE)' Journal of Biomechanics, vol 49, no. 7, pp. 1009-15.

  12. Chunhui Li, Chris Kennedy, and Ghulam Nabi, Optimized Retroperitoneoscopic Excision of Large (>25 cm) Adult Polycystic Kidneys Using 3-Dimensional Image Reconstruction and Preresection Ultrasound-Guided Aspiration: Technique and Early Outcomes SURG INNOV., accepted in printing (2015).

  13. Chunhui Li, Tuo Zang, Karolina Wrobel, Jeffrey T.-J. Huang, Ghulam Nabi. "Quantitative urinary proteomics using stable isotope labelling by peptide dimethylation in patients with prostate cancer", Analytical and Bioanalytical Chemistry, DOI 10.1007/s00216-015-8569-6, (2015). (IF: 3.66)

  14. Chunhui Li, Guangying Guan, Yuting Ling, Ying-ting Hsu, Shaozhen Song, Jeffrey T. J. Huang, Stephen Lang, Zhihong Huang and Ghulam Nabi, ‘Detection and characterisation of biopsy tissue using quantitative optical coherence elastogaphy (OCE) in men with suspected prostate cancer’, Cancer Letters, 2014, accepted in printing. (IF: 5.016)

  15. Chunhui Li, Guangying Guan, Fan Zhang, Ruikang K. Wang, Zhihong Huang, and Ghulam Nabi, ‘Quantitative elasticity measurement of urinary bladder wall using laser-induced surface acoustic waves’, Biomedical Optics Express, 2014, 5(12): 4313–4328. (IF: 3.497)

  16. Chunhui Li, Guangying Guan, Fan Zhang, Ghulam Nabi, Ruikang K. Wang and Zhihong Hhuang, ‘Laser induced surface acoustic wave combined with phase sensitive optical coherence tomography for superficial tissue characterization: a solution for practical application’, Biomedical Optics Express,Vol. 5, Issue 5, pp. 1403-1418 (2014). (IF: 3.497)

  17. Guan, G, Li, C, Ling, Y, Yang, Y, Vorstius, JB, Keatch, RP, Wang, RK & Huang, Z 2013, 'Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method' Journal of Biomedical Optics, vol 18, no. 11, 111417. (IF: 2.752)

  18. Chunhui Li, Guangying Guan, Zhihong Huang, Murray Johnstone, and Ruikang K. Wang. “Non-contact all-optical measurement of corneal elasticity”, Optics Letters 37, 1625-1627 (2012) (IF: 3.179)

  19. Chunhui Li, Guangying Guan, Sinan Li, Zhihong Huang, and Ruikang K. Wang. “Evaluating elastic properties of heterogeneous soft tissue by surface acoustic waves detected by phase-sensitive optical coherence tomography”, Journal of Biomedical Optics, Vol. 17, Issue 5, 2012. (IF: 2.752)

  20. Chunhui Li, Guangying Guan, Xi Cheng, Zhihong Huang, and Ruikang K. Wang*, “Quantitative elastography provided by surface acoustic waves measured by phase-sensitive optical coherence tomography”, Optics Letters, Vol. 37, Issue 4, pp. 722-724 (2012). (IF: 3.179)

  21. Chunhui Li, Guangying Guan, Roberto Reif, Zhihong Huang*, and Ruikang K. Wang*, “Determining elastic properties of skin by measuring surface waves from an impulse mechanical stimulus using phase-sensitive optical coherence tomography”, Journal of the Royal Society Interface, doi: 10.1098/rsif.2011.0583, 2011. (IF: 4.907)

  22. Chunhui Li, Shaozhen Song, Guanying Guan, Ruikang K. Wang, Zhihong Huang, “Frequency dependence of laser ultrasonic SAW phase velocities measurements” Ultrasonics, vol. 53 (1), pp. 191-195, 2012.

  23. Chunhui Li, Sinan Li, Guangying Guan, Cheng Wei, Zhihong Huang,* and Ruikang K. Wang, “A comparison of laser ultrasound measurements and finite element simulations for evaluating the elastic properties of tissue mimicking phantoms”, Optics and laser technology, 44(4), 866-871, 2012.ISSN 0030-3992, 10.1016/j.optlastec.2011.11.017. (IF: 1.649)

  24. Yi Wang, Chunhui Li, and Ruikang Wang. “Non-contact photoacoustic imaging by using a low coherence interferometer as the acoustic detector” Optics Letters 36(20), 3975-3977, (2011).   doi:10.1364/OL.36.003975. (IF: 3.179)

  25. Chunhui Li, Zhihong Huang, Ruikang K. Wang, “Elastic properties of soft tissue-mimicking phantoms assessed by combined use of laser ultrasonics and low coherence interferometry”, Optics Express Vol. 19, Iss. 11, pp. 10153–10163 (2011) (IF: 3.525)

  26. Chunhui Li, Sinan Li, Zhihong Huang, Wenbin Xu, “Skin Thermal Effect by FE Simulation and Experiment of Laser Ultrasonics”, Applied Mechanics and Materials 2010, Vols. 24-25, pp 281-286.

  27. Guangying Guan, Chunhui Li, Hui Shi, “Optical coherence tomography (OCT) in Brain and neural imaging”, International Journal of Biomedical Engineering, 2008, vol. 31, issue. 6, pp. 342-347.

  28. Li Chunhui and Zhu Xianfeng, “Detecting and Controlling System of Ozone Water Concentration in the Waterline of Dental Instruments”, Biomedical engineering and Clinical medicine vol. 11 April 2007 pp 52-53


Peer reviewed conference paper

  1. Yuting Ling, Chunhui Li, Christine Purslow, Ying Yang, Zhihong Huang, "Evaluation of human corneal ulcer healing process using optical coherence tomography: an in vitro study," Proc. SPIE 10880, Optical Elastography and Tissue Biomechanics VI, 108801H (21 February 2019); https://doi.org/10.1117/12.2509486

  2. Kanheng Zhou, Kairui Feng, Chunhui Li. Zhihong Huang, Paul O’Mahoney, Ewan Eadie, Sally Helen Ibbotson, Structural characterization on in vitro porcine skin treated by ablative fractional laser using optical coherence tomography, 2018 DOI 10.1117/12.2288492 Conference: Optical Elastography and Tissue Biomechanics V SPIE DOI 10.1117/12.2288503, Conference: Optical Elastography and Tissue Biomechanics V SPIE

  3. Kanheng Zhou, Kairui Feng, Chunhui Li and Zhihong Huang, The potential of high intensity focused ultrasound (HIFU) combine phase-sensitive optical coherence tomography (PhS-OCT) for diseases diagnosis, treatment and monitoring, 2018 DOI 10.1117/12.2288498 Conference: Optical Elastography and Tissue Biomechanics V SPIE

  4. Kanheng Zhou, Kairui Feng, Mingkai Wang, Tanatswa Jamera, Chunhui Li and Zhihong Huang, High resolution SAW elastography for ex-vivo porcine skin specimen, Proceedings Volume 10496, Optical Elastography and Tissue Biomechanics V; 104960I (2018).

  5. Quantitative assessment of the mechanical properties of prostate tissue with optical coherence elastography, Yuting Ling, Chunhui Li, Kanheng Zhou, Guangying Guan, Stephen Lang, David McGloin, Ghulam Nabi, Zhihong Huang, 2018/2/7, Therapeutics and Diagnostics in Urology 2018,10468(104680A)

  6. Chunhui Li, Guangying Guan, Zhihong Huang, Ruikang K. Wang, Ghulam Nabi; “Full skin quantitative optical coherence elastography achieved by combining vibration and surface acoustic wave methods”. Proc. SPIE 9322, Dynamics and Fluctuations in Biomedical Photonics XII, 93220O (2015).

  7. Chunhui Li, Guangying Guan, Yuting Ling, Stephen Lang, Ruikang K. Wang, Zhihong Huang, Ghulam Nabi. “Optical coherence elastography (OCE) as a method for identifying benign and malignant prostate biopsies.” Proc. SPIE 9312, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX, 93122S (2015).

  8. Chunhui Li, Zhihong Huang, Ruikang K. Wang, “Characterisation of skin layer properties using laser-generated surface acoustic waves validated by FEM method”, BIOS SPIE Photonics West 2011, Paper 7898-30.

  9. Zhu Xiafeng, Liu Chang, Li Chunhui, Liu Tiegen and Wang Mingshi, “Photograph high speed object using low speed camera in image flow cytometry”, CBME’ 09.

  10. Chunhui Li, Andreas Melzer, “New devices robotics assisted MRI guided breast procedures”, NRP 2009.


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