维普医疗科学家简介：谭炳尧

主要教育和工作经历

 博士后研究员 2018 – current

化学生物工程学院，南洋理工大学，新加坡(世界工程排名:4 ,QSrankings) 新加坡眼科研究所

导师: Leopold Schmetterer
主要工作: 转化实验室眼科成像系统应用于动物以及临床研究

 物理系博士 2012 – 2017

滑铁卢大学，加拿大 (世界工程系排名:38, 世界物理系排名:51 博士论文课题: 结合光相关断层成像与视网膜电图技术于研究动物青光眼模型

副课题: 使用高分辨 OCT 解析眼前节细胞结构
导师: Kostadinka Bizheva
委员会:Donna Strickland (2018 物理诺奖); Kelvin Resch; Simpson Treffold.

 访问学者 2019

杜克眼科中心/生物工程系，杜克大学，美国

课题:眼底结构重建以及曲率计算 导师:Anthony Kuo/ Joseph Izatt

主要教学经历

本科生(n>10)毕设/实习指导 助教 (10 学期，110 小时/学期) 物理天文系，滑铁卢大学

 几何光学/物理光学  生物物理成像方法  大学物理
 生物力学

获奖经历 (博士期间)

•    校友**提名, 滑铁卢大学, 加拿大

•    加拿大自然科学博士基金, 滑铁卢大学，加拿大

•    玛丽居里奖, 滑铁卢大学, 加拿大

•    ARVO – 美国眼科研究协会

•    IEEE – 电气工程师协会

•    SPIE – 国际光学光电子协会

•    APOIS – 亚太眼科成像协会

•    BSC – 加拿大生物物理协会

  期刊审稿

•    眼科及其他期刊 (Scientific Reports, Current Eye Research, BMC Ophthalmology, etc.) 期刊发表:

, QS rankings)

协会会员

 光学期刊 (Optics Letters, Optics Express, Biomedical Optics Express, Applied Optics, Journal of Biomedical Optics)

通信作者

1. Liu X, Ke M, Yao X, Chua J, Schmetterer L, Tan B. Stable complex conjugate artifact removal in OCT using circularly polarized light as reference. Opt Lett. 2020 Jul 15;45(14):3977-3980. doi: 10.1364/OL.395860. PMID: 32667332. 运用偏振光实现全纵深OCT

2. Saxena A, Chua J, Yao X, Wong D, Schmetterer L, Tan B. A framework for quantitative three- dimensional choroidal vasculature analysis using optical coherence tomography. Biomedical Optics Express (已接收). 三维脉络膜血管量化分析

3. Wu X, Chua J, Ho C, Yao X, Muralidharan AR, Najjar RP, Tan G, Tamm ER, Schmetterer L, Barathi VA, Tan B. In vivo imaging of ocular microvasculature using swept source optical coherence tomography angiography in seven lab species. TVST (修改中). 实验室动物模型的眼底血管成像

**作者

- 动物实验

1. Tan B, Barathi VA, Lin E, Ho C, Gan A, Yao X, Chan A, Wong DWK, Chua J, Tan GS, Schmetterer

   L. Longitudinal Structural and Microvascular Observation in RCS Rat Eyes Using Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2020 Jun 3;61(6):54. doi: 10.1167/iovs.61.6.54. PMID: 32579681; PMCID: PMC7415900. 使用OCT研究一种视锥细胞病变 动物模型

2. Tan B, Chua J, Barathi VA, Baskaran M, Chan A, Lin E, Ang M, Klose G, Schmetterer L. Quantitative analysis of choriocapillaris in non-human primates using swept-source optical coherence tomography angiography (SS-OCTA). Biomed Opt Express. 2018 Dec 21;10(1):356-371. doi: 10.1364/BOE.10.000356. PMID: 30775105; PMCID: PMC6363185. 灵长动物脉络膜广西血管量 化

3. Tan B, MacLellan B, Mason E, Bizheva K. Structural, functional and blood perfusion changes in the rat retina associated with elevated intraocular pressure, measured simultaneously with a combined OCT+ERG system. PLoS One. 2018 Mar 6;13(3):e0193592. doi: 10.1371/journal.pone.0193592. PMID: 29509807; PMCID: PMC5839563. OCT/OCTA应用于动物青光眼模型

4. Tan B, Mason E, MacLellan B, Bizheva KK. Correlation of Visually Evoked Functional and Blood Flow Changes in the Rat Retina Measured With a Combined OCT+ERG System. Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1673-1681. doi: 10.1167/iovs.17-21543. PMID: 28319641. 使用OCT与视 网膜电图研究视网膜血流对于外界光刺激下的变化

5. Tan B, MacLellan B, Mason E, Bizheva KK. The Effect of Acutely Elevated Intraocular Pressure on the Functional and Blood Flow Responses of the Rat Retina to Flicker Stimulation. Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5532-5540. doi: 10.1167/iovs.17-22412. PMID: 29075764. 在高眼压模型下使用OCT与视网膜电图研究视网膜血流对于外界光刺激下的变化

6. Tan B, Gurdita A, Choh V, Joos KM, Prasad R, Bizheva K. Morphological and functional changes in the rat retina associated with 2 months of intermittent moderate intraocular pressure elevation. Sci Rep. 2018 May 16;8(1):7727. doi: 10.1038/s41598-018-25938-z. PMID: 29769654; PMCID: PMC5955988. OCT/OCTA/视网膜电图应用于动物慢性青光眼模型

- 人眼实验/临床实验

1. Tan B, McNabb RP, Zheng F, Yao X, Chua J, Ang M, Hoang QV, Kuo A, Schmetterer L. Ultrawide

   Field, Distortion-Corrected Ocular Shape Estimation with MHz Optical Coherence Tomography (OCT). Biomed Opt Express. (修改中) 应用MHz超快，超广域OCT重建眼底曲率，杜克大学合 作项目

2. Tan B, Sim YC, Chua J, Yusufi D, Wong D, Yow AP, Chin C, Tan ACS, Sng CCA, Agrawal R, Gopal L, Sim R, Tan G, Lamoureux E, Schmetterer L. Developing a Normative Database for Wide- Field Retinal Perfusion using Optical Coherence Tomography Angiography. Biomed Opt Express. (已接收即将出版) 联合新加坡五所大型眼科医院应用AI算法建立广域OCTA标准数据集

3. Tan B, Hosseinaee Z, Han L, Kralj O, Sorbara L, Bizheva K. 250 kHz, 1.5 μm resolution SD-OCT for in-vivo cellular imaging of the human cornea. Biomed Opt Express. 2018 Nov 29;9(12):6569- 6583. doi: 10.1364/BOE.9.006569. PMID: 31065450; PMCID: PMC6490998.

4. Tan B, Hosseinaee Z, Han L, Kralj O, Sorbara L, Bizheva K. 250 kHz, 1.5 μm resolution SD-OCT for in-vivo cellular imaging of the human cornea. Biomed Opt Express. 2018 Nov 29;9(12):6569- 6583. doi: 10.1364/BOE.9.006569. PMID: 31065450; PMCID: PMC6490998. 高分辨OCT应用于解 析人眼眼角膜的细胞结构

5. Tan B, Chua J, Lin E, Cheng J, Gan A, Yao X, Wong DWK, Sabanayagam C, Wong D, Chan CM, Wong TY, Schmetterer L, Tan GS. Quantitative Microvascular Analysis With Wide-Field Optical Coherence Tomography Angiography in Eyes With Diabetic Retinopathy. JAMA Netw Open. 2020 Jan 3;3(1):e1919469. doi: 10.1001/jamanetworkopen.2019.19469. PMID: 31951275; PMCID: PMC6991275.糖网病人广域OCTA图像量化

6. Tan B, Sim R, Chua J, Wong D.W.E, Yao X, Garhöfer G, Schmidl D, Werkmeister RM, Schmetterer L., Approaches to optical coherence tomography angiography metrics. Annals of Translational Medicine. ATM-2020-OCT-03. OCTA图像量化综述(约稿)

7. Tan B, Chua J, Harish T, Lau A, Gan ATL, Tan YL, Wong DWK, Chong RS, Ang M, Husain R, Schmetterer L. Comparison of a commercial spectral-domain OCT and swept-source OCT based on an angiography scan for measuring circumpapillary retinal nerve fibre layer thickness. Br J Ophthalmol. 2020 Jul;104(7):974-979. doi: 10.1136/bjophthalmol-2019-314706. Epub 2019 Oct 4. PMID: 31585965; PMCID: PMC7361033.

- 算法/实验方法

1. Tan B, Wong A, Bizheva K. Enhancement of morphological and vascular features in OCT images

   using a modified Bayesian residual transform. Biomed Opt Express. 2018 Apr 27;9(5):2394-2406. doi: 10.1364/BOE.9.002394. PMID: 29760996; PMCID: PMC5946797. 基于贝叶斯理论的 OCT/OCTA图像信息提取

2. Tan B, Hosseinaee Z, Bizheva K. Dense concentric circle scanning protocol for measuring pulsatile retinal blood flow in rats with Doppler optical coherence tomography. J Biomed Opt. 2017 Nov;22(11):1-4. doi: 10.1117/1.JBO.22.11.110501. PMID: 29110446. 多普勒OCT实现视网膜血流 脉动探测

- 另(共一作/导师一作)

1. Bizheva K, Tan B, MacLelan B, Kralj O, Hajialamdari M, Hileeto D, Sorbara L. Sub-micrometer

   axial resolution OCT for in-vivo imaging of the cellular structure of healthy and keratoconic human corneas. Biomed Opt Express. 2017 Jan 12;8(2):800-812. doi: 10.1364/BOE.8.000800. PMID: 28270986; PMCID: PMC5330551.

2. Bizheva K, Tan B, MacLellan B, Hosseinaee Z, Mason E, Hileeto D, Sorbara L. In-vivo imaging of the palisades of Vogt and the limbal crypts with sub- micrometer axial resolution optical coherence tomography. Biomed Opt Express. 2017 Aug 17;8(9):4141-4151. doi: 10.1364/BOE.8.004141. PMID: 28966853; PMCID: PMC5611929.

3. Hosseinaee Z, Tan B, Martinez A, Bizheva KK. Comparative Study of Optical Coherence Tomography Angiography and Phase-Resolved Doppler Optical Coherence Tomography for Measurement of Retinal Blood Vessels Caliber. Transl Vis Sci Technol. 2018 Aug 24;7(4):18. doi: 10.1167/tvst.7.4.18. PMID: 30159211; PMCID: PMC6108529. 共同一作

全部发表期刊列表:

Pubmed Record Google scholar page

主要发表期刊:

Ophthalmology
JAMA Network Open
British Journal of Ophthalmology