维普医疗科学家简介:上官光英

2021-06-04 12:38

英国邓迪大学电子工程与物理博士,

研究方向:生物医用光子学、光学相干成像以及其功能性成像的技术开发、医学仪器开发、系统控制、材料分析

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研究经历

2014-2016 年,英国诺丁汉大学制造与工艺技术分院工程系,谢菲尔德大学电子与电气工程系

Adam Clare 教授及其诺丁汉大学团队开展添加剂制造研究,配合谢菲尔德大学Kristian Groom 博士领导的光学实验室从事以下项目:


  • OCT 在添加剂制造应用中的可行性研究。

  • 通过OCT 现场检测选择性激光烧结流程。


2010-2014 年,英国邓迪大学工程、数学与物理学院,华盛顿大学生物工程系

  • 双摄像头OCT 血管成像开发。

  • 将光热OCT 应用于鼠淋巴结的金纳米颗粒分布成像

  • 利用OCT 预测药物浓度并成像

  • 利用相敏感OCT 体外和体内测量豚鼠人工耳蜗的微结构和振动

  • 开发定量OCT 算法

  • 利用表面声波(SAW) 方法,结合相敏OCT (PhS-OCT),定量确定皮肤的生物力学特性

  • 测量用于组织工程的台架的机械特性


2009 年,邓迪大学工程、数学与物理学院。

  • TMM 超声波影像研究开发


2006-2007 天津大学精密仪表和光电子工程学院

  • 设计用于临床应用的THz 探测传感器

  • 成像流式细胞仪

  • 用于ECG EEG 的放大器


PUBLICATIONS

Peer reviewed journal paper

  1. Ling Yuting, Chunhui Li, Kanheng Zhou, Guangying Guan, Paul L Appleton, stephen Lang, David McGloin, Zhihong Huang & Ghulam Nabi, Microscale characterization of prostate biopsies tissues using optical coherence elastography and second harmonic generation imaging, Laboratory Investigation volume 98, pages 380-390 (2017)

  2. Hirsch, Matthias & Patel, Rikesh & Li, Wenqi & Guan, Guangying & Leach Richard & D. Sharples, steve & Clare, Adam. (2016) Assessing the capability of in-situ nondestructive analysis during layer based additive manufacture. Additive Manufacturing. 13. 135-142

  3. Guan G, Hirsch M, Syam W P, et al. Loose powder detection and surface characterization in selective laser sintering via optical coherence tomography[C]//Proc. R. Soc. A. The Royal Society, 2016, 472(2191): 20160201. (IF: 2.05)

  4. Guangying Guan, Matthias Hirsch, Zeng Hai Lu, David T D Childs, Stephen J Matcher, Ruth Goodridge, Kristian M Groom, Adam T Clare, ‘Evaluation of Selective Laser Sintering Processes by Optical Coherence Tomography’, Materials & Design. 2015;88:837-46. (IF: 3.997)

  5. Chunhui Li, Guangying Guan, Yuting Ling, Ying-Ting Hsu, Shaozhen Song, Jeffrey T.-J. Huang, Stephen Lang, Ruikang K. Wang, Zhihong Huang and Ghulam Nabi, ‘Detection and characterisation of biopsy tissue using quantitative optical coherence elastogaphy (OCE) in men with suspected prostate cancer’, Cancer Letters, 2015, 357(1): 121-128. (IF: 5.016)

  6. Chunhui Li, Guangying Guan, Fan Zhang, Ruikang K. Wang, Zhihong Huang, and Ghulam Nabi, ‘Quantitative elasticity measurement of urinary bladder wall using laser-induced surface acoustic waves’, Biomedical Optics Express, 2014, 5(12): 4313–4328. (IF: 3.497)

  7. Chunhui Li, Guangying Guan, Fan Zhang, Ghulam Nabi, Ruikang K. Wang and Zhihong Hhuang, ‘Laser induced surface acoustic wave combined with phase sensitive optical coherence tomography for superficial tissue characterization: a solution for practical application’, Biomedical Optics Express, 2014, 5(5): 1403-1418. (IF: 3.497)

  8. Guan, G, Li, C, Ling, Y, Yang, Y, Vorstius, JB, Keatch, RP, Wang, RK & Huang, Z, 'Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method' Journal of Biomedical Optics, vol. 18, no. 11, 111417 (2013). (IF: 2.752)

  9. Chunhui Li, Shaozhen Song, Guangying Guan, Ruikang K Wang, Zhihong Huang, “Frequency dependence of laser ultrasonic SAW phase velocities measurements.”, Ultrasonics. 06/2012; DOI:10.1016/j.ultras.2012.05.009 (IF: 1.649)

  10. Chunhui Li, Guangying Guan, Sinan Li, Zhihong Huang, Ruikang K Wang, “Evaluating elastic properties of heterogeneous soft tissue by surface acoustic waves detected by phase-sensitive optical coherence tomography.” Journal of Biomedical Optics. 05/2012; 17(5):057002. (IF: 2.752)

  11. Chunhui Li, G Guan, Z Huang, M Johnstone, R K Wang, “Noncontact all-optical measurement of corneal elasticity.” Optics Letters. 05/2012; 37(10):1625-7. (IF: 3.179)

  12. Chunhui Li, Guangying Guan, Xi Cheng, Zhihong Huang, Ruikang K Wang, “Quantitative elastography provided by surface acoustic waves measured by phase-sensitive optical coherence tomography.” Optics Letters. 02/2012; 37(4):722-4. (IF: 3.179)

  13. Yeongri Jung, Guangying Guan, Chen-Wei Wei, Roberto Reif, Xiaohu Gao, Matthew O'Donnell, Ruikang K Wang, “Multifunctional nanoprobe to enhance the utility of optical based imaging techniques.” Journal of Biomedical Optics. 01/2012; 17(1):016015. (IF: 2.752)

  14. Chunhui Li, Sinan Li, Guangying Guan, Cheng Wei, Zhihong Huang, Ruikang K Wang, “A comparison of laser ultrasound measurements and finite element simulations for evaluating the elastic properties of tissue mimicking phantoms”, Optics & Laser Technology. 01/2012; 44:866 - 871. (IF: 1.649)

  15. Guangying Guan, Roberto Reif, Zhihong Huang, Ruikang K Wang, “Depth profiling of photothermal compound concentrations using phase sensitive optical coherence tomography.”Journal of Biomedical Optics. 12/2011; 16(12):126003. (IF: 2.752)

  16. Chunhui Li, Guangying Guan, Roberto Reif, Zhihong Huang, Ruikang K Wang, “Determining elastic properties of skin by measuring surface waves from an impulse mechanical stimulus using phase-sensitive optical coherence tomography.” Journal of The Royal Society Interface. 11/2011; 9(70):831-41. (IF: 4.907)

  17. Lin An, Guangying Guan, Ruikang K Wang, “High-speed 1310 nm-band spectral domain optical coherence tomography at 184,000 lines per second”, Journal of Biomedical Optics. 06/2011; 16(6):060506. (IF: 2.752)

  18. Guangying Guan, Chunhui Li, Hui Shi, “Optical coherence tomography (OCT) in Brain and neural imaging”, International Journal of Biomedical Engineering, 2008, vol. 31, issue. 6, pp. 342-347.


Peer reviewed conference paper

  1. Guan G, Song S, Huang Z, et al. Application of new optical coherence elastography to monitor the mineralization processing in bone tissue engineering constructs[C]//SPIE BiOS. International Society for Optics and Photonics, 2015: 93220G-93220G-8.

  2. Guangying Guan; Roberto Reif; Ruikang K. Wang, “Depth profile absorber concentration reconstruction using photothermal optical coherence tomography” Proc. SPIE 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI, 82132G (February 9, 2012);


技能

研究项目管理与数据分析的常规技能。具体专业技术和兴趣:

计算机技能:     

  • 编程语言:MatlabC++ LabView

  • 影像处理和分割

  • CAD 设计:Auto CAD SolidWorks

  • 3D 可视化工具:Amira

  • 数据库系统quartzy


研究技能:   

  • 光学(OCT、显微镜和SEM et.al)和超声波影像系统开发与运行。

  • 生物医学光学,包括高能激光脉冲系统、干涉仪和光学相干断层扫描。

  • 影像处理和算法开发。

  • 模拟和数字电技术。

  • 动物操作和组织操作,包括细胞、鼠、灵长类和体外人体组织。